产品名称

利福喷丁(Rifapentine)

一般描述

Rifapentine (利福喷丁) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to  treat mycobacterium infections.

别 称

Priftin; Cyclopentylrifampicin;  Rifapentinum; Rifapentina; DL 473

纯 度

≥99%(HPLC)

CAS NO.

61379-65-5

分子式

C⁴⁷H⁶⁴N⁴O¹²

分子量

877.045

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

砖红色或暗红色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥10mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Rifapentine is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most  gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial  infections and a few other indications. Rifampin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Rifapentine is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov