产品名称

那可汀(Narcotine)

一般描述

Noscapine(那可丁) is a phthalide isoquinoline non-narcotic alkaloid derived from the opium  poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities.

别 称

(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one;  Terbenol; Tusscapine;

纯 度

≥99%(HPLC)

CAS NO.

128-62-1

分子式

C²²H²³NO⁷

分子量

413.426

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

~2mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Noscapine is a phthalide isoquinoline non-narcotic alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities.  Noscapine exerts its antitussive effects through the activation of sigma opioid receptors. This agent appears to exert its antimitotic effect by binding to tubulin, resulting in a disruption of microtubule assembly dynamics and subsequently, the inhibition of mitosis and tumor cell death.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov