产品名称

槲皮素(Quercetin)

一般描述

Quercetin(槲皮素) is a polyphenolic flavonoid with potential chemopreventive activity.

别 称

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one;  Sophoretin; Xanthaurine; Meletin; Quercetol

纯 度

≥98%(HPLC)

CAS NO.

117-39-5

分子式

C¹⁵H¹⁰O⁷

分子量

302.238

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~10mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Quercetin is a polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce  antiproliferative effects resulting from the modulation of either EGFR or  estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase  and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of  the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov