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Obeticholic Acid

商品编号: TL0192
图示 货号 库存 价格(¥) 数量

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详细介绍

l  基本信息

产品名称

奥贝胆酸(Obeticholic Acid)

一般描述

Obeticholic acid(奥贝胆酸)  is a synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR).

别 称

(4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic  acid; INT-747; 6-ECDCA

纯 度

≥98%(HPLC)

CAS NO.

459789-99-2

分子式

C26H44O4

分子量

420.634

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

Insoluble

l  生物学信息

生物活性/药理作用

Obeticholic acid (OCA) is a synthetically modified bile acid and potent agonist of the farnesoid X nuclear receptor (FXR) that is used to treat liver diseases including primary biliary cholangitis. Obeticholic acid has not been ed to elevations in serum  enzyme levels during therapy, but has been ed to an increased rate of  severe liver related adverse events such as ascites, jaundice and liver failure.

l  包装与存储

包 装

50mg; 250mg

存储温度

0-5

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov