产品名称

酒石酸长春瑞滨(Vinorelbine Tartrate)

一般描述

Vinorelbine Tartrate(酒石酸长春瑞滨) is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin.

别 称

3′ ,4′  -Didehydro-4′ -deoxy-C′ -norvincaleukoblastine  [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt]; KW-2307, NVB, Navelbine  tartrate

纯 度

≥98%(HPLC)

CAS NO.

125317-39-7

分子式

C⁴⁵H⁵⁴N⁴O⁸ · 2C⁴H⁶O⁶

分子量

1079.11

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Vinorelbine Tartrate is the ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity,  whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine  is more selective against mitotic than axonal microtubules in vitro, which  may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent.

l  包装与存储

包 装

10mg; 25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov