产品名称

紫杉醇(Paclitaxel)

一般描述

Paclitaxel(紫杉醇),  a cyclodecane isolated from the bark of the Pacific yew tree, is a  Microtubule Inhibitor.

别 称

Taxol

纯 度

≥99%(HPLC)

CAS NO.

33069-62-4

分子式

C⁴⁷H⁵¹NO¹⁴

分子量

853.918

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥15mg/mL

水

≥10mg/mL

l  生物学信息

生物活性/药理作用

Paclitaxel is a taxoid antineoplastic agent indicated as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast cancer.  Paclitaxel is a novel antimicrotubule agent that promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing  depolymerization. This stability results in the inhibition of the normal dynamic reorganization of the microtubule network that is essential for vital interphase and mitotic cellular functions. In addition, paclitaxel induces  abnormal arrays or "bundles" of microtubules throughout the cell  cycle and multiple asters of microtubules during mitosis.

Paclitaxel is a compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by  binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2).

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov