产品名称

多西他赛三水合物(Docetaxel  trihydrate)

一般描述

Docetaxel(多西他赛),  a semi-synthetic, second-generation taxane, is an inhibitor of  depolymerisation of microtubules by binding to stabilized microtubules,  displays potent and broad antineoplastic properties.

别 称

RP56976 (NSC 628503) Trihydrate

纯 度

≥99%(HPLC)

CAS NO.

148408-66-6

分子式

C⁴³H⁵³NO¹⁴ · 3H²O

分子量

861.93

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting  microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov