产品名称

利血平(Reserpine)

一般描述

Reserpine(利血平) is an alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects.

别 称

(3β, 16β, 17α, 18β,  20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester

纯 度

≥98%(HPLC)

CAS NO.

50-55-5

分子式

C³³H⁴⁰N²O⁹

分子量

608.688

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或浅黄色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine  are a result of its ability to deplete catecholamines from peripheral  sympathetic nerve endings. These substances are normally involved in  controlling heart rate, force of cardiac contraction and peripheral  resistance.

Reserpine is an alkaloid, derived from the  roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can  penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into  presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and  serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects.

l  包装与存储

包 装

50mg; 250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov