产品名称

硫酸原黄素(Proflavine Hemisulfate Hydrate)

一般描述

Proflavine Hemisulfate(硫酸原黄素), an acridine-derived fluorescent contrast and disinfectant agent, exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA  synthesis and halting bacterial cell growth.

别 称

3,6-Diaminoacridine hemisulfate salt; 原黄素半硫酸盐; Proflavin  hemisulfate

纯 度

≥98%(HPLC)

CAS NO.

1811-28-5

分子式

C¹³H¹¹N³·0.5 H²SO⁴

分子量

258.29

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

深红色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥20mg/mL

l  生物学信息

生物活性/药理作用

Proflavine is an acriflavine derivative which is a disinfectant bacteriostatic against many gram-positive bacteria. Proflavine is toxic and carcinogenic in mammals and so it is used only as a surface disinfectant or for treating superficial wounds.

Proflavine Hemisulfate is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and  antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby  accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth.

l  包装与存储

包 装

1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov