一般描述 | Berberine chloride(盐酸小檗碱)
is a quaternary ammonium salt from the group of isoquinoline alkaloids with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. |
生物活性/药理作用 | Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese
herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory,
anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to tranion factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1),
B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl),
cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6,
IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1),
hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of
tranion 3 (STAT3), peroxisome proliferator-activated receptor (PPAR) arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene may induce cell cycle arrest and apoptosis, and
inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism. |
