产品名称

秋水仙素(Colchicine)

一般描述

Colchicine(秋水仙素),  an alkaloid isolated from Colchicum autumnale, is a microtubule polymerization inhibitor with anti-gout and anti-inflammatory activities.

别 称

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; 秋水仙碱;  Colchicina; Colchicin; Condylon; Colchicinum

纯 度

≥98%(HPLC)

CAS NO.

64-86-8

分子式

C²²H²⁵NO⁶

分子量

399.44

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Colchicine is a highly poisonous alkaloid, originally extracted from plants of the genus Colchicum (Autumn crocus, also known as the "Meadow saffron"). Originally used to treat rheumatic  complaints and especially gout, it was also prescribed for its cathartic and  emetic effects. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition.

Colchicine is an alkaloid isolated from Colchicum autumnale with anti-gout and anti-inflammatory activities. The  exact mechanism of action by which colchicines exerts its effect has not been completely established. Colchicine binds to tubulin, thereby interfering with the polymerization of tubulin, interrupting microtubule dynamics, and disrupting mitosis. This leads to an inhibition of migration of leukocytes  and other inflammatory cells, thereby reducing the inflammatory response to deposited urate crystals. Colchicine may also interrupt the cycle of  monosodium urate crystal deposition in joint tissues, thereby also preventing the resultant inflammatory response. Overall, colchicine decreases leukocyte chemotaxis/migration and phagocytosis to inflamed areas, and inhibits the formation and release of a chemotactic glycoprotein that is produced during  phagocytosis of urate crystals.

l  包装与存储

包 装

50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov