产品名称

硫酸长春新碱(Vincristine sulfate)

一般描述

Vincristine Sulfate(硫酸长春新碱) is the sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus with antimitotic and antineoplastic activities.

别 称

22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR

纯 度

≥98%(HPLC)

CAS NO.

2068-78-2

分子式

C⁴⁶H⁵⁶N⁴O¹⁰ · H²SO⁴

分子量

923.04

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Vincristine Sulfate is the sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea  L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby  arresting tumor cells in metaphase. This agent also depolymerizes  microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov