Lapatinib Ditosylate
商品编号:
TL0246
备注:
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详细介绍
l 基本信息 |
产品名称 | 二对甲苯磺酸拉帕替尼(Lapatinib Ditosylate) |
一般描述 | Lapatinib Ditosylate(二对甲苯磺酸拉帕替尼)
is a tyrosine kinase receptor inhibitor used in the therapy of advanced
breast cancer and other solid tumors. |
别 称 | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic
acid |
纯 度 | ≥99%(HPLC) | CAS NO. | 388082-77-7 |
分子式 | C43H42ClFN4O10S3 | 分子量 | 925.455 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 浅黄色或黄色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | Insoluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Lapatinib Ditosylate is the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types. |
l 包装与存储 |
包 装 | 1g |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |