产品名称

奎宁(Quinine)

一般描述

Quinidine(奎宁) is an alkaloid extracted from the bark of the Cinchona tree with antiarrhythmic and antimalarial effects.

别 称

(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; Qualaquin

纯 度

≥99%(HPLC)

CAS NO.

130-95-0

分子式

C²⁰H²⁴N²O²

分子量

324.424

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

l  生物学信息

生物活性/药理作用

Quinine is used parenterally to treat life-threatening infections caused by chloroquine-resistant Plasmodium falciparum malaria. Quinine acts as a blood schizonticide although it also has gametocytocidal  activity against P. vivax and P. malariae. Because it is a weak base, it is concentrated in the food vacuoles of P. falciparum. It is thought to act by inhibiting heme polymerase, thereby allowing accumulation of its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective and more toxic than chloroquine. However, it has a special place in the management of severe falciparum malaria in areas with known resistance to chloroquine.

l  包装与存储

包 装

5g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov