产品名称

雷替曲塞(Raltitrexed)

一般描述

Raltitrexed(雷替曲塞), quinazoline folate analogue with antineoplastic activity, is a thymidylate synthase inhibitor.

别 称

(2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid; Tomudex; ZD1694; ICI-D1694; ZD-1694

纯 度

≥98%(HPLC)

CAS NO.

112887-68-0

分子式

C²¹H²²N⁴O⁶S

分子量

458.489

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Raltitrexed belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum.  It may also be used to treat other kinds of cancer, as determined by your doctor. Raltitrexed blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious  but may cause concern.

Raltitrexed is a quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity.

l  包装与存储

包 装

25mg; 100mg; 250mg;

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov