产品名称

艾代拉里斯(Idelalisib)

一般描述

Idelalisib(艾代拉里斯)  is Kinase Inhibitor, and Cytochrome P450 3A Inhibitor.

别 称

5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one; CAL-101; GS-1101

纯 度

≥98%(HPLC)

CAS NO.

870281-82-6

分子式

C²²H¹⁸FN⁷O

分子量

415.432

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥20mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Idelalisib is an orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell  proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted  inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov