产品名称

康普瑞汀磷酸二钠(Fosbretabulin Disodium)

一般描述

Fosbretabulin Disodium(康普瑞汀磷酸二钠)  is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow with potential vascular disrupting and antineoplastic activities.

别 称

disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate; 康布瑞汀磷酸二钠;Combretastatin  A4 Phosphate; CA4DP

纯 度

≥98%(HPLC)

CAS NO.

168555-66-6

分子式

C¹⁸H¹⁹Na²O⁸P

分子量

440.295

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥25mg/mL

l  生物学信息

生物活性/药理作用

Fosbretabulin Disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the  engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/beta-catenin/Akt signaling pathway, which may result in the  inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue.

l  包装与存储

包 装

10mg; 25mg; 100mg;

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov