产品名称

N-[2-[2-(4-氯苯基)-4-噻唑基]乙基]丁酰胺(Azoramide)

一般描述

Azoramide is a small-molecule modulator of the unfolded protein response (UPR) that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress.

别 称

N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide;  AK163919

纯 度

≥98%(HPLC)

CAS NO.

932986-18-0

分子式

C¹⁵H¹⁷ClN²OS

分子量

308.824

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It has dual activity: Azoramide  improves endoplasmic reticulum (ER) protein-folding ability and stimulates the of ER chaperones that protect cells against ER stress. Azoramide was shown to protect cells from death and dysfunction in multiple models of ER stress. It showed antidiabetic activity in two independent mouse models of obesity by improving insulin sensitivity and protecting pancreatic β cell function against ER stress.

l  包装与存储

包 装

10mg; 50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov