产品名称

阿折地平(Azelnidipine)

一般描述

Azelnidipine(阿折地平)  is a dihydropyridine calcium channel blocker. Unlike nicardipine, it has a  gradual onset and has a long-lasting hypotensive effect, with little increase in heart rate.

别 称

3-(1-benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; CS-905

纯 度

≥99%(HPLC)

CAS NO.

123524-52-7

分子式

C³³H³⁴N⁴O⁶

分子量

582.657

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Azelnidipine is a vasodilator that induces a gradual decrease in blood pressure in hypertensive patients. Unlike other members of its drug class, azelnidipine does not induce reflex tachycardia due to vasodilation. This is likely due to the fact that it elicits a gradual  fall in blood pressure It also exhibits a prolonged hypotensive effect and  has been shown to have a strong anti-arteriosclerotic action in vessels due to its high affinity for vascular tissue and antioxidative activity. Clinical  studies have demonstrated that azelnidipine markedly reduced heart rate and  proteinuria in hypertensive patients by inhibiting sympathetic nerve activity. Azelnidipine has also been confirmed to have cardio-protective, neuroprotective, and anti-atherosclerotic properties, and has also been found to prevent insulin resistance.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov