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Azithromycin

商品编号: TL0287
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详细介绍

l  基本信息

产品名称

阿奇霉素(Azithromycin)

一般描述

Azithromycin(阿奇霉素) is an azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and bacteriostatic activities.

别 称

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;  Zithromax; Azithromycine; Azithromycinum; Azitrocin

纯 度

≥99%(HPLC)

CAS NO.

83905-01-5

分子式

C38H72N2O12

分子量

748.996

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

Insoluble

l  生物学信息

生物活性/药理作用

Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory  disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex  (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.

Azithromycin is an azalide, derived from erythromycin, and a member of a subclass of macrolide antibiotics with bacteriocidal and  bacteriostatic activities. Azithromycin reversibly binds to the 50S ribosomal subunit of the 70S ribosome of sensitive microorganisms, thereby inhibiting  the translocation step of protein synthesis, wherein a newly synthesized peptidyl tRNA molecule moves from the acceptor site on the ribosome to the peptidyl (donor) site, and consequently inhibiting RNA-dependent protein synthesis leading to cell growth inhibition and cell death.

l  包装与存储

包 装

1g

存储温度

0-5

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov