产品名称

吡喹酮(Praziquantel)

一般描述

Praziquantel(吡喹酮) is a pyrazinoisoquinoline derivative with anthelminthic property.

别 称

2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one; Biltricide; Droncit; Pyquiton; Cesol

纯 度

≥98%(HPLC)

CAS NO.

55268-74-1

分子式

C¹⁹H²⁴N²O²

分子量

312.413

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Praziquantel is an anthelmintic used in most schistosome and many cestode infestations. Praziquantel effects the permeability of the cell membrane resulting in the contraction of schistosomes. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An increased calcium influx may play an important role. Secondary effects are inhibition of glucose uptake, lowering of glycogen levels and stimulation of lactate release. The action of praziquantel is limited very specifically to trematodes and cestodes; nematodes (including  filariae) are not affected.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov