产品名称

吡罗昔康(Piroxicam)

一般描述

Piroxicam(吡罗昔康), a non-selective COX inhibitor,is a Nonsteroidal Anti-inflammatory Drug.

别 称

Feldene; Piroxicamum; Pyroxycam; Roxicam

纯 度

≥98%(HPLC)

CAS NO.

36322-90-4

分子式

C¹⁵H¹³N³O⁴S

分子量

331.346

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~1mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov