产品名称

非诺贝特(Fenofibrate)

一般描述

Fenofibrate(非诺贝特), a Peroxisome Proliferator Receptor alpha Agonist, is an antilipemic agent which reduces both cholesterol and triglycerides in the blood.

别 称

propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate; Procetofen;  Lipanthyl; Lipantil

纯 度

≥98%(HPLC)

CAS NO.

49562-28-9

分子式

C²⁰H²¹ClO⁴

分子量

360.834

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥40mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Fenofibrate is a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity. Fenofibrate is hydrolyzed in vivo to its active metabolite  fenofibric acid that binds to and activates peroxisome proliferator activated receptor alpha (PPARalpha), resulting in the activation of lipoprotein lipase and reduction of the production of apoprotein C-III, an inhibitor of lipoprotein lipase activity. Increased lipolysis and a fall in plasma triglycerides, in turn, leads to the modification of the small, dense low density lipoporotein (LDL) particles into larger particles that are catabolized more rapidly due to a greater affinity for cholesterol receptors. In addition, activation of PPARalpha also increases the synthesis of apoproteins A-I, A-II, and high density lipoprotein (HDL)-cholesterol. Overall, fenofibrate reduces total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein  (VLDL) while increasing HDL cholesterol.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.   https://www.ncbi.nlm.nih.gov