产品名称

卡托普利(Captopril)

一般描述

Captopril(卡托普利), a sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity, is an Angiotensin Converting Enzyme Inhibitor.

别 称

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline;  Capoten; L-Captopril; Lopirin; Captopryl

纯 度

≥98%(HPLC)

CAS NO.

62571-86-2

分子式

C⁹H¹⁵NO³S

分子量

217.29

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

≥40mg/mL

水

≥20mg/mL

l  生物学信息

生物活性/药理作用

Captopril is a sulfhydryl-containing analog of proline with antihypertensive activity and potential antineoplastic activity. Captopril competitively inhibits angiotensin converting enzyme (ACE), thereby decreasing levels of angiotensin II, increasing plasma renin activity, and decreasing aldosterone secretion. This agent may also inhibit  tumor angiogenesis by inhibiting endothelial cell matrix metalloproteinases (MMPs) and endothelial cell migration. Captopril may also exhibit antineoplastic activity independent of effects on tumor angiogenesis.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov