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详细介绍
l 基本信息 |
产品名称 | 坎地沙坦(Candesartan) |
一般描述 | Candesartan(坎地沙坦) is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. |
别 称 | 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid; Blopress; Ratacand;
CV-11974 |
纯 度 | ≥98%(HPLC) | CAS NO. | 139481-59-7 |
分子式 | C24H20N6O3 | 分子量 | 440.463 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | ~1mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Candesartan is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure. |
l 包装与存储 |
包 装 | 1g |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |