产品名称

磷酸氯喹(Chloroquine diphosphate)

一般描述

Chloroquine Phosphate(磷酸氯喹) is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.

别 称

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;phosphoric acid; Chloroquine phosphate;  Aralen phosphate; Chingamin phosphate; Chloroquine bis(phosphate)

纯 度

≥98%(HPLC)

CAS NO.

50-63-5

分子式

C¹⁸H²⁶ClN³ · 2H³PO⁴

分子量

515.86

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum.  Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov