产品名称

马来酸依那普利(Enalapril Maleate)

一般描述

EEnalapril Maleate(马来酸依那普利) is an angiotensin-converting enzyme (ACE) inhibitor widely used in the therapy of hypertension and heart failure.

别 称

(S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro  maleate salt; Renitec;  Glioten; Vasotec; Baripril

纯 度

≥98%(HPLC)

CAS NO.

76095-16-4

分子式

C²⁰H²⁸N²O⁵ · C⁴H⁴O⁴

分子量

492.52

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

~4mg/mL

水

Sparingly  soluble

l  生物学信息

生物活性/药理作用

Enalapril Maleate is the maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov