产品名称

司他夫定(Stavudine)

一般描述

Stavudine(司他夫定) is a nucleoside reverse tranase inhibitor analog of thymidine.

别 称

1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine; BMY-27857;Sanilvudine;NSC 163661

纯 度

≥98%(HPLC)

CAS NO.

3056-17-5

分子式

C¹⁰H¹²N²O⁴

分子量

224.21

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

≥10mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Stavudine is a nucleoside reverse tranase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Stavudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse tranase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue  prevents the formation of the 5' to 3' phosphodiester age essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Stavudine is a nucleoside reverse tranase inhibitor analog of thymidine. Stavudine has been recommended to undergo phase-out management due to its long-term, irreversible side-effects.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov