产品名称

托灭酸(Tolfenamic acid)

一般描述

Tolfenamic acid(托灭酸) is a COX inhibitor and prevents formation of prostaglandins.

别 称

2-([3-Chloro-2-methylphenyl]amino)benzoic acid; N-(3-氯-2-甲苯基)邻氨基苯甲酸

纯 度

≥98%(HPLC)

CAS NO.

13710-19-5

分子式

C¹⁴H¹²ClNO²

分子量

261.7

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥45mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Studies have shown that tolfenamic acid presents a non-dose dependent partial inhibition of irritant-induced temperature rise as well as a dose-dependent inhibition of skin edema. By studying its NSAID properties more closely, it was noted a dose-related inhibition of serum thromboxane which indicated the inhibition of COX-1. In the same line, there was noted a inhibition of prostaglandin E2 synthesis which marks a related COX-2 inhibition. The maximal inhibition of thromboxane was greater than 80% as well as is proven to be a potent prostaglandin E inhibitor.

l  包装与存储

包 装

1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov