产品名称

盐酸阿那格雷(Anagrelide Hydrochloride)

一般描述

Anagrelide Hydrochloride(盐酸阿那格雷) is an antithrombotic and platelet reducing agent that is used to treat the  thrombocythemia associated with myeloproliferative diseases.

别 称

6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-2(3H)-one  hydrochloride

纯 度

≥98%(HPLC)

CAS NO.

58579-51-4

分子式

C¹⁰H⁷Cl²N³O · HCl

分子量

292.55

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥10mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Anagrelide Hydrochloride is the hydrochloride salt of a synthetic quinazoline derivative, Anagrelide Hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for  treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis.

l  包装与存储

包 装

50mg; 250mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov