产品名称

盐酸度洛西汀(Duloxetine Hydrochloride)

一般描述

Duloxetine Hydrochloride(盐酸度洛西汀) is a fluoxetine derivative belonging to the class of selective serotonin and  norepinephrine reuptake inhibitors and exhibiting antidepressant activity.

别 称

(+)-(S)-N-Methyl-γ-(1-naphthyloxy)-2-thiophenepropylamine hydrochloride; LY-248686 hydrochloride

纯 度

≥98%(HPLC)

CAS NO.

136434-34-9

分子式

C¹⁸H¹⁹NOS · HCl

分子量

333.88

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Duloxetine Hydrochloride is the hydrochloride salt of duloxetine, a fluoxetine derivative belonging to the class of selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitors (SSNRIs) and exhibiting antidepressant activity. Duloxetine selectively prevents the reuptake of 5-HT and NE via transporter complexes on the pre-synaptic membrane, thereby increasing the level of these neurotransmitters within the synaptic cleft. As a result, this agent potentiates serotonergic and noradrenergic activities in the central nervous system, and alleviates depression and neuropathy sensations, such as pain and tingling. Furthermore, duloxetine does not show significant affinity for dopaminergic, adrenergic,cholinergic,histaminergic,opioid, glutamate, and gamma-aminobutyric acid (GABA) receptors.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov