产品名称

盐酸米诺环素(Minocycline hydrochloride)

一般描述

Minocycline Hydrochloride(盐酸米诺环素) is a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities.

别 称

(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride

纯 度

≥98%(HPLC)

CAS NO.

13614-98-7

分子式

C²³H²⁷N³O⁷ · HCl

分子量

493.94

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色固体

溶解性(25℃)

DMSO

Insoluble

乙醇

Insoluble

水

≥10mg/mL

l  生物学信息

生物活性/药理作用

Minocycline Hydrochloride is the hydrochloride salt of minocycline, a broad spectrum long-acting derivative of the antibiotic tetracycline, with antibacterial and anti-inflammatory activities. Minocycline binds to the bacterial 30S ribosomal subunit and interferes with the binding of tRNA to the ribosomal complex, thereby inhibiting protein translation in bacteria. In addition, minocycline inhibits the inflammatory enzyme 5-lipoxygenase (5LOX) and may impede T cell-microglia interactions; both activities may contribute to minocycline's neuroprotective effects. 5LOX catalyzes the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.

l  包装与存储

包 装

250mg;  1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov