产品名称

利福布汀(Rifabutin)

一般描述

Rifabutin(利福布汀) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

别 称

Ansamycin; Ansatipine; Farmitalia;  LM-427;Mycobutin

纯 度

≥99%(HPLC)

CAS NO.

72559-06-9

分子式

C⁴⁶H⁶²N⁴O¹¹

分子量

847.00

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

紫色或浅紫色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥35mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Rifabutin is an antibiotic that inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterial RNA polymerase but does not inhibit the mammalian enzyme. It is bactericidal and has a very broad spectrum of activity against most gram-positive and gram-negative organisms (including Pseudomonas aeruginosa) and specifically Mycobacterium tuberculosis. Because of rapid emergence of resistant bacteria, use is restricted to treatment of mycobacterial infections and a few other indications.Rifabutin is well absorbed when taken orally and is distributed widely in body tissues and fluids, including the CSF. It is metabolized in the liver and eliminated in bile and, to a much lesser extent, in urine, but dose adjustments are unnecessary with renal insufficiency.

Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA  formation and leading to inhibition of RNA synthesis and tranion.

l  包装与存储

包 装

250mg; 1g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov