产品名称

比伐卢定三氟醋酸盐(Bivalirudin trifluoroacetate salt)

一般描述

Bivalirudin trifluoroacetate salt(比伐卢定三氟醋酸盐) is a specific and reversible bivalent direct thrombin inhibitor.

别 称

D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-aspariginylglycyl-L-α-aspartyl-L-phenylalanyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-α-glutamyl-L-α-glutamyl-L-tyrosyl-L-leucine trifluoroacetate; Hirulog trifluoroacetate salt

纯 度

≥98%(HPLC)

CAS NO.

128270-60-0   (free base)

分子式

C⁹⁸H¹³⁸N²⁴O³³ · xC²HF³O²

分子量

2180.29   (free base basis)

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

l  生物学信息

生物活性/药理作用

Bivalirudin directly and reversibly inhibits thrombin by specifically binding both to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. The action of bivalirudin is reversible because thrombin will slowly cleave the   thrombin-bivalirudin bond which recovers the active site of thrombin.

Bivalirudin is a 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina.

l  包装与存储

包 装

25mg; 100mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov