产品名称

克唑替尼(Crizotinib)

一般描述

Crizotinib(克唑替尼) is an orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity.

别 称

(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine; (R)-crizotinib; PF-2341066; PF-02341066

纯 度

≥98%(HPLC)

CAS NO.

877399-52-5

分子式

C²¹H²²Cl²FN⁵O

分子量

450.34

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

黄白色固体

溶解性(25℃)

DMSO

~9mg/mL

乙醇

Insoluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Crizotinib is an orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib  inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

l  包装与存储

包 装

25mg; 100mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov