产品名称

噻奈普汀(Tianeptine)

一般描述

Tianeptine(噻奈普汀) is a drug used primarily in the treatment of major depressive disorder.

别 称

S-1574,  JNJ-39823277, TPI-1062

纯 度

≥98%(HPLC)

CAS NO.

66981-73-5

分子式

C²¹H²⁵ClN²O⁴S

分子量

436.95

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

l  生物学信息

生物活性/药理作用

Tianeptine is a distinctive antidepressant and anxiolytic medication that stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in brain tissu. Although the monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) are proven to be related to the occurrence of depressive disorders, it is now recognized that monoamine deficits are not sufficient to explain the mechanism of action of antidepressant medications. Current research suggests that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity  (for example, AMPA receptors and NMDA receptors) and affect the release of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity. Tianeptine reduces the hypothalamic-pituitary-adrenal response to stress, and thus prevents stress-related behavioral issues. Tianeptine is effective in reducing depressive symptoms in mild to severe major depressive disorder and also alleviates anxious symptoms associated with depression without the need  for coadministration of an anti-anxiety medication. These findings, however, are met with controversial data. In a study of healthy volunteers, Tianeptine-treated subjects were less accurate at identifying facial s, suggesting a lack of improvement in the psychomotor symptoms of depression. The tianeptine group also showed reduced memory and reduced attentional vigilance to various stimuli.

l  包装与存储

包 装

25mg; 100mg; 250mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov