Irinotecan hydrochloride trihydrate
商品编号：
TL0473
备注：
库存充足，如需更大包装，请联系销售人员，大包装有极大的折扣优惠！
详细介绍
l 基本信息 |
产品名称 | 盐酸伊立替康三水合物(Irinotecan hydrochloride trihydrate) |
一般描述 | Irinotecan(盐酸伊立替康),
a prodrug, is converted to a biologically active metabolite SN-38 by a carboxylesterase-converting enzyme. |
别 称 | Irinotecan monohydrochloride trihydrate; Irinotecan HCl Trihydrate; CPT-11 |
纯 度 | ≥99.0%(HPLC) | CAS NO. | 136572-09-3 |
分子式 | C33H45ClN4O9 | 分子量 | 677.18 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 浅黄色至黄色固体 |
溶解性(25℃) | DMSO | ≥50mg/mL |
乙醇 | Slightly soluble |
水 | Slightly soluble |
l 生物学信息 |
生物活性/药理作用 | Irinotecan Hydrochloride is the
hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its
parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. |
l 包装与存储 |
包 装 | 25mg; 100mg; 250mg; 1g |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
