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详细介绍
l 基本信息 |
产品名称 | 塞卡替尼(Saracatinib) |
一般描述 | Saracatinib(塞卡替尼) is a potent Src inhibitor |
别 称 | N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine; AZD0530 |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 379231-04-6 |
分子式 | C27H32ClN5O5 | 分子量 | 542.033 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 固体 |
溶解性(25℃) | DMSO | ≥25mg/mL |
乙醇 | ≥25mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Saracatinib is an orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein
tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption. |
l 包装与存储 |
包 装 | 5mg; 25mg; 100mg |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
