产品名称

Apalutamide(ARN-509)

一般描述

Apalutamide is a small molecule and androgen receptor antagonist with potential antineoplastic activity.

别 称

4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide; Apalutamide

纯 度

≥98.0%(HPLC)

CAS NO.

956104-40-8

分子式

C²¹H¹⁵F⁴N⁵O²S

分子量

477.438

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

溶解性(25℃)

DMSO

≥15mg/mL

乙醇

≥5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.  Apalutamide binds to AR in target tissues thereby preventing androgen-induced  receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and  tranion of AR-responsive genes. This ultimately inhibits the of genes that regulate prostate cancer cell proliferation and may lead to an inhibition of cell growth in AR-expressing tumor cells.

l  包装与存储

包 装

5mg; 25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov