产品名称

达沙替尼盐酸盐(Dasatinib hydrochloride)

一般描述

Dasatinib hydrochloride(达沙替尼盐酸盐) is a pyrimidine and thiazole derived antineoplastic agent and protein kinase inhibitor of BCR-ABL kinase.

别 称

N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;hydrochloride; BMS 354825 hydrochloride

纯 度

≥99.0%(HPLC)

CAS NO.

854001-07-3

分子式

C²²H²⁷Cl²N⁷O²S

分子量

524.465

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或浅黄色固体

溶解性(25℃)

DMSO

≥25mg/mL

乙醇

Slightly soluble

水

≥25mg/mL(warmed)

l  生物学信息

生物活性/药理作用

Dasatinib is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases.  Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase  domain point mutations. SRC-family protein-tyrosine kinases interact with  variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or of the endogenous protein and by way of virally-encoded kinase  genes.

l  包装与存储

包 装

10mg; 50mg; 200mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov