产品名称

吉非替尼盐酸盐(Gefitinib hydrochloride)

一般描述

Gefitinib hydrochloride(吉非替尼盐酸盐) is a selective tyrosine kinase receptor inhibitor.

别 称

N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine;hydrochloride; ZD-1839 hydrochloride

纯 度

≥99.0%(HPLC)

CAS NO.

184475-55-6

分子式

C²²H²⁵Cl²FN⁴O³

分子量

483.365

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或浅黄色固体

溶解性(25℃)

DMSO

≥5mg/mL

乙醇

Slightly soluble

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Gefitinib is an anilinoquinazoline with antineoplastic activity. Gefitinib inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor  (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis.

l  包装与存储

包 装

10mg; 50mg; 200mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov