Apatinib mesylate
商品编号:
TL0488
备注:
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详细介绍
l 基本信息 |
产品名称 | 甲磺酸阿帕替尼(Apatinib mesylate) |
一般描述 | Apatinib mesylate(甲磺酸阿帕替尼) is an orally bioavailable, selective VEGFR2 inhibitor. |
别 称 | N-[4-(1-cyanocyclopentyl)phenyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;methanesulfonic acid; Apatinib; YN968D1 |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 1218779-75-9 |
分子式 | C25H27N5O4S | 分子量 | 493.582 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25℃) | DMSO | ≥20mg/mL |
乙醇 | Insoluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Apatinib is an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Apatinib selectively binds to
and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases. |
l 包装与存储 |
包 装 | 10mg; 25mg; 100mg |
存储温度 | 0-5℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |