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详细介绍
l 基本信息 |
产品名称 | 达帕菲尼(Dabrafenib) |
一般描述 | Dabrafenib(达帕菲尼) is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. |
别 称 | N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide; GSK 2118436 |
纯 度 | ≥99.0%(HPLC) | CAS NO. | 1195765-45-7 |
分子式 | C23H20F3N5O2S2 | 分子量 | 519.56 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 白色或类白色固体 |
溶解性(25℃) | DMSO | ≥25mg/mL |
乙醇 | Very slightly soluble |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 | Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. |
l 包装与存储 |
包 装 | 10mg; 25mg; 100mg; 500mg |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
