产品名称

6-重氮-5-氧代-L-正亮氨酸((L)-DON)

一般描述

6-Diazo-5-oxo-L-norleucine (DON) is a glutamine analogue.

别 称

(Z,5S)-5-amino-1-diazonio-6-hydroxy-6-oxohex-1-en-2-olate; 6-Diazo-5-oxo-L-norleucine

纯 度

≥95.0%(TLC)

CAS NO.

157-03-9

分子式

C⁶H⁹N³O³

分子量

171.156

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

l  生物学信息

生物活性/药理作用

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

应 用

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

l  包装与存储

包 装

5mg; 10mg; 25mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov