产品名称

硫酸氯喹(Chloroquine sulfate)

一般描述

Chloroquine Sulfate(硫酸氯喹) is the sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties.

别 称

4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;sulfuric acid

纯 度

≥98.0%(HPLC)

CAS NO.

132-73-0

分子式

C¹⁸H²⁸ClN³O⁴S

分子量

417.949

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色固体

溶解性(25℃)

DMSO

Slightly soluble

乙醇

Slightly soluble

水

≥50mg/mL

l  生物学信息

生物活性/药理作用

Chloroquine Sulfate is the sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.

l  包装与存储

包 装

100mg; 250mg; 1g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov