产品名称

依那普利钠盐(Enalapril sodium)

一般描述

Enalapril sodium(依那普利钠盐) is the sodium salt of Enalapril, which is an angiotensin-converting enzyme (ACE) inhibitor.

别 称

sodium;(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylate;enalapril sodium salt

纯 度

≥98.0%(HPLC)

CAS   NO.

149404-21-7

分子式

C²⁰H²⁷N²NaO⁵

分子量

398.435

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

类白色或浅黄色至深黄色固体

l  生物学信息

生物活性/药理作用

Enalapril is a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE)   inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

l  包装与存储

包 装

50mg; 250mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov