产品名称

阿仑膦酸钠三水合物(Alendronate sodium trihydrate)

一般描述

Alendronate Sodium(阿仑膦酸钠三水合物) is a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity.

别 称

sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate;trihydrate;MK 217; G-704650

纯 度

≥98.0%(HPLC)

CAS NO.

121268-17-5

分子式

C⁴H¹⁸NNaO¹⁰P²

分子量

325.122

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

Very slightly soluble

乙醇

Very slightly soluble

水

≥10mg/mL

l  生物学信息

生物活性/药理作用

Alendronate Sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small   GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced.

l  包装与存储

包 装

1g; 5g

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov