产品名称

硝酸益康唑(Econazole nitrate)

一般描述

Econazole Nitrate(硝酸益康唑) is an imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties.

别 称

1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole;NSC 243115

纯 度

≥99.0%(HPLC)

CAS   NO.

24169-02-6

分子式

C¹⁸H¹⁶Cl³N³O4

分子量

444.70

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Slightly soluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Econazole Nitrate is an imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components. In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity which  may contribute to cellular necrosis and cell death. Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various dermatomycoses.

l  包装与存储

包 装

1g; 5g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov