产品名称

醋甲唑胺(Methazolamide)

一般描述

Methazolamide(醋甲唑胺) is a sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity.

别 称

N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide;CL 8490

纯 度

≥99.0%(HPLC)

CAS NO.

554-57-4

分子式

C⁵H⁸N⁴O³S²

分子量

236.27

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥40mg/mL

乙醇

Slightly soluble

水

Very slightly soluble

l  生物学信息

生物活性/药理作用

Methazolamide is a sulfonamide derivate and carbonic anhydrase inhibitor with potential antineoplastic activity. Methazolamide inhibits tumor-associated carbonic anhydrase IX (CAIX), which may result in increased cell death in hypoxic tumors. As a hypoxia-inducible transmembrane glycoprotein, CAIX catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions, helping to maintain acidification of the tumor microenvironment and enhance resistance to cytotoxic therapy in some hypoxic tumors.

l  包装与存储

包 装

250mg; 1g; 5g

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov