产品名称

波生坦一水物(Bosentan hydrate)

一般描述

Bosentan(波生坦) is a sulfonamide-derived, competitive and specific endothelin receptor   antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor.

别 称

4-tert-Butyl-N-[6-(2-hydroxyethoxy)- 5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzenesulfonamide;Bosentan; Ro 47-0203

纯 度

≥97.0%(HPLC)

CAS   NO.

157212-55-0

分子式

C²⁷H³¹N⁵O⁷S

分子量

569.63

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

Slightly soluble

水

Insoluble

l  生物学信息

生物活性/药理作用

Bosentan is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular   resistance and is particularly used in the treatment of pulmonary arterial hypertension.

l  包装与存储

包 装

50mg

存储温度

0-5℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov